CD45 (PTPRC) Rat Monoclonal Antibody [Clone ID: YTH24.5]

CAT#: SM1744PT

CD45 (PTPRC) rat monoclonal antibody, clone YTH24.5, Purified


USD 190.00

5 Days*

Size
    • 25 ug

Product Images

Specifications

Product Data
Clone Name YTH24.5
Applications FC, IHC
Recommended Dilution Flow Cytometry: Use 10 µl of 1/10-1/100 diluted antibody to label 106 cells in 100 µl. 
Immunohistochemistry on Paraffin Sections: 10 µg/ml.
Reactivities Human
Host Rat
Isotype IgG2b
Clonality Monoclonal
Immunogen Human T lymphocytes.
Specificity This antibody recognises the leukocyte common antigen CD45, expressed on all cells of haematopoietic origin except for erythrocytes. The isolation and characterization of this cell line was carried out with the help of funds supplied by the Medical Research Council, United Kingdom.
Formulation PBS
State: Purified
State: Liquid purified IgG fraction
Preservative: 0.09% Sodium Azide
Concentration lot specific
Purification Affinity Chromatography on Protein A
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background CD45 is a family of single chain transmembraneous glycoproteins consisting of at least four isoforms (220, 205, 190, 180 kDa) which share a common large intracellular domain. Their extracellular domains are heavily glycosylated. The different isoforms are produced by alternative messenger RNA splicing of three exons of a single gene on chromosome 1. CD45 is expressed on cells of the human hematopoietic lineage (including hematopoietic stem cells) with the exception of mature red cells. It is not detected on differentiated cells of other tissues. It is likely that CD45 plays an important role in signal transduction, inhibition or upregulation of various immunological functions. Antibodies recognising a common epitope on all of the isoforms are termed CD45 whilst those recognising only individual isoforms are termed CD45RA or CD45RO etc.
Synonyms PTPRC, Leukocyte common antigen, L-CA, T200
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.