CD59 Rat Monoclonal Antibody [Clone ID: YTH53.1]

CAT#: SM1768R

CD59 rat monoclonal antibody, clone YTH53.1, PE


USD 495.00

5 Days*

Size
    • 100 Tests

Product Images

Specifications

Product Data
Clone Name YTH53.1
Applications FC
Recommended Dilution Flow cytometry: We do not recommend using this antibody in lysed whole blood techniques due to inhibition of staining caused by CD59 expression on erythrocytes.
Reactivities Human
Host Rat
Isotype IgG2b
Clonality Monoclonal
Immunogen Human Peripheral Blood T cells. Spleen cells from immunised DA rat fused with the Y3/Ag1.2.3 meloma cell line.
Specificity Clustered at the fourth leucocyte typing workshop to designation CD59. YTH53.1 reacts with CD59 transfectants. It enhances antibody-mediated lysis by homologous complement and reacts with GPI-linked antigen of 18-20kD size which is broadly expressed on human leucocytes and erythrocytes. Putative ligand for CD2.
Formulation PBS, pH7.2 containing 0.09% Sodium Azide and 1% Bovine Serum Albumin
Label: PE
State: Lyophilized purified IgG
Label: R. Phycoerythrin (RPE)
Reconstitution Method Restore with 1 ml distilled water
Purification Ion exchange chromatography
Conjugation PE
Storage Prior to and following reconstitution store the antibody at 2-8°C.
DO NOT FREEZE!
This product is photosensitive and should be protected from light.
Stability Shelf life: one year from despatch.
Background CD59, an LY6 like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. It is a potent inhibitor of the complement membrane attack complex action. It acts by binding to the C8 and/or C9 complements of the membrane attack complex, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
Synonyms MAC-inhibitory protein, Protectin, MEM43 antigen, MIC11, MIN1, MIN2, MIN3, MSK21, MACIF, MAC-IP, MIRL, HRF20, HRF-20
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.