CD46 Mouse Monoclonal Antibody [Clone ID: MEM-258]

CAT#: SM1819AC

CD46 mouse monoclonal antibody, clone MEM-258, APC


USD 300.00

2 Weeks*

Size
    • 100 Tests

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Specifications

Product Data
Clone Name MEM-258
Applications FC
Recommended Dilution Flow Cytometry analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension.
The content of a vial (1 ml) is sufficient for 100 tests.
Reactivities Bovine, Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen HPB-ALL human T cell line
Specificity This antibody recognizes an epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 kDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast; it is negative on erythrocytes.
Formulation Phosphate buffered saline (PBS) solution containing 15mM sodium azide
Label: APC
State: Liquid purified Ig fraction
Label: Conjugated with cross-linked Allophycocyanin under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
Conjugation APC
Storage Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens CD46 molecule (CD46), transcript variant a
Background CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.
Synonyms TLX, MIC10
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Complement and coagulation cascades

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.