CD180 / RP105 Rat Monoclonal Antibody [Clone ID: RP/14]

CAT#: SM1823PS

CD180 / RP105 rat monoclonal antibody, clone RP/14, Purified


USD 365.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name RP/14
Applications FC, FN
Recommended Dilution Flow cytometry: The typical starting working dilution is 1:50.
Functional assays (B cell activation).
Reactivities Mouse
Host Rat
Isotype IgG2a
Clonality Monoclonal
Specificity This antibody reacts with Radioprotective 105 (RP105, CD180).
Formulation PBS
State: Purified
State: Liquid 0.2 µm filtered Ig fraction
Stabilizer: 0.1% bovine serum albumin
Concentration 0.1 mg/ml
Purification Protein G
Background


Radioprotective 105 (RP105, CD180) is a type 1 transmembrane protein of 105 kDa with extracellular leucine-rich repeats (LLRs) and a short cytoplasmic tail. RP105, assigned as CD180, is similar to Drosophila Toll in the extracellular LLRs. Radioprotective 105 (RP105, CD180) expression is largely restricted to immune cells including CD19+ B cells and macrophages. Histological studies showed that RP105 is expressed mainly on mature B cells in mantle zones. Antibody-mediated (RP/14) cross-linking of RP105 induces resistance against irradiation-induced apoptosis, B-cell proliferation, and up-regulation of a costimulatory molecule B7.2, revealing RP105 as a potent regulator of B-cell activation. RP105 (CD180) has an important role in B-cell activation by LPS. It is important to note that RP105 associates with MD1, which is in this context important for RP105 with respect to B-cell surface expression and LPS recognition and signalling. MD-1 seems to be requisite for efficient expression of RP105.

Synonyms LY64
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.