CD11c (ITGAX) Mouse Monoclonal Antibody [Clone ID: BU15]

CAT#: SM1834PP

CD11c (ITGAX) mouse monoclonal antibody, clone BU15, PerCP

Product Images

Surface staining of human peripheral blood cells with anti-CD11c (BU15) PerCP.

Specifications

Product Data

• Clone Name: BU15
• Applications: FC
• Recommended Dilution: Flow Cytometry analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 10⁶ cells in a suspension.
  The content of a vial (1 ml) is sufficient for 100 tests.
• Reactivities: Human, Monkey
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Dendritic cells of synovial fluid
• Specificity: This antibody reacts with CD11c (alphaX, p150), a 150 kDa integrin expressed mainly on dendritic cells and tissue macrophages.
• Formulation: stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide
  Label: PerCP
  State: Liquid purified Ig fraction
  Label: Conjugated with Peridinin-chlorophyll-protein complex (PerCP) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
• Conjugation: PerCP
• Database Link:
  Entrez Gene 3687 Human
• Background: CD11c (p150, alphaX integrin subunit) forms complex with CD18 (beta2 integrin subunit) and is expressed mainly on tissue macrophages and dendritic cells. CD11c binds to complement fragment iC3b, fibrinogen, VCAM-1 and ICAM-2 or e.g. CD90. Like other beta2 integrins, CD11c/CD18 plays roles in cell migration and phagocytosis. Moreover, interaction of CD11c/CD18 with plasminogen regulates plasmin activities, and interaction with heparin counteracts binding of iC3b.
• Synonyms: ITGAX, Integrin alpha-X, Leu M5