Clec7a Rat Monoclonal Antibody [Clone ID: 2A11]

CAT#: SM2025B

Clec7a rat monoclonal antibody, clone 2A11, Biotin


USD 505.00

5 Days*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name 2A11
Applications FC
Recommended Dilution Flow Cytometry: Neat - 1/10; Use 10µl of the suggested working dilution to label 10e6 cells in 100µl.
Reactivities Mouse
Host Rat
Isotype IgG2b
Clonality Monoclonal
Immunogen Dectin-1 transfected NIH3T3 cells and recombinant soluble Dectin-1. Spleen cells from immunised Fischer rats were fused with cells of the rat Y3 myeloma cell line.
Specificity This antibody recognises beta-glucan receptor, also known as Dectin-1. This antibody inhibits the binding of zymosan to macrophages via the beta-glucan receptor. The low endotoxin version (SM2025LE) is recommended for functional studies.
Formulation PBS, pH 7.4 containing 0.09% Sodium Azide and 1% Bovine Serum Albumin
Label: Biotin
State: Liquid purified IgG
Concentration 0.1 mg/ml
Purification Affinity chromatography on Protein G
Conjugation Biotin
Background Dectin-1 is predominantly expressed by cells of the monocyte/macrophage and neutrophil lineages, but also at lower levels by dendritic cells and a subpopulation of T cells. As a major leucocyte receptor for beta-glucan this molecule may have a key role in the immunomodulatory effects of beta-glucans and in the host response to fungal pathogens. Recent work has shown that Dectin-1 may stimulate reactive oxygen production in macropahges via the protein tyrosine kinase known as Syk.
Synonyms Beta-glucan receptor, BGR, CLECSF12, DECTIN1
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.