Clec7a Rat Monoclonal Antibody [Clone ID: 2A11]

CAT#: SM2025R

Clec7a rat monoclonal antibody, clone 2A11, PE


USD 620.00

5 Days*

Size
    • 100 Tests

Product Images

Specifications

Product Data
Clone Name 2A11
Applications FC
Recommended Dilution Flow Cytometry (Neat -1/10): Use 10 ul of the suggested working dilution to label 10e6 cells in 100 ul.
Reactivities Mouse
Host Rat
Isotype IgG2b
Clonality Monoclonal
Immunogen Dectin-1 transfected NIH3T3 cells and recombinant soluble Dectin-1.
Spleen cells from immunised Fischer rats were fused with cells of the rat Y3 myeloma cell line2
Specificity Recognises Murine Beta-Glucan Receptor (Dectin-1).
This antibody inhibits the binding of zymosan to macrophages via the beta-glucan receptor. The low endotoxin version SM2025LE is recommended for Functional Studies.
Formulation PBS containing 0.09% Sodium Azide as preservative and 1% BSA and 5% sucrose as stabilizers.
Label: PE
State: Lyophilized purified IgG fraction.
Label: R. Phycoerythrin (RPE)
Reconstitution Method Restore with 1 ml distilled water
Purification Affinity Chromatography on Protein G.
Conjugation PE
Background Dectin-1 is predominantly expressed by cells of the monocyte/macrophage and neutrophil lineages, but also at lower levels by dendritic cells and a subpopulation of T cells.
As a major leucocyte receptor for beta-glucan this molecule may have a key role in the immunomodulatory effects of beta-glucans and in the host response to fungal pathogens.
Recent work has shown that Dectin-1 may stimulate reactive oxygen production in macropahges via the protein tyrosine kinase known as Syk.
Synonyms Beta-glucan receptor, BGR, CLECSF12, DECTIN1
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.