Desmoglein 3 (DSG3) Mouse Monoclonal Antibody [Clone ID: 5G11]

CAT#: SM2037PS

Desmoglein 3 (DSG3) mouse monoclonal antibody, clone 5G11, Purified

Specifications

Product Data

• Clone Name: 5G11
• Applications: IF, IHC, IP, WB
• Recommended Dilution: Immunofluorescence: The typical starting working dilution is 1/10.
  Immunoprecipitation.
  Immunohistochemistry on Frozen Sections.
  Immunohistochemistry on Paraffin Sections.
  Western blot: The typical starting working dilution is 1/10.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Specificity: The monoclonal antibody 5G11 reacts with the 140 kDa Desmoglein-3 protein and is not cross reactive with Desmoglein-1 or Desmoglein-2.
• Formulation: PBS
  State: Purified
  State: Liquid 0.2 µm filtered Ig fraction
  Stabilizer: 0.1% BSA
  Preservative: 0.02% Sodium Azide
• Concentration: lot specific
• Purification: Protein G Chromatography
• Storage: Store undiluted at 2-8°C.
  DO NOT FREEZE!
  
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 1830 Human
• Background: Desmoglein 3 is a member of the desmosomal cadherin family that comprise the desmogleins and desmocollins. Desmosomes are cell-cell junctions in most epithelial cells and serve to link the intermediate filament cytoskeletons of adjacent cells. Within the desmosome the extracellular domain of desmoglein is essential for calcium dependent heterophilic binding to the desmocollins, whereas the intracellular domain is essential for binding to the desmosomal plaque protein, plakoglobin. Desmoglein 3 is synthesized in both the basal and the lower suprabasal compartments.
• Synonyms: DSG3, CDHF6, PVA, 130 kDa pemphigus vulgaris antigen