Adenovirus (Hexon) Mouse Monoclonal Antibody [Clone ID: B025 (AD51)]

CAT#: SM2078P

Adenovirus (Hexon) mouse monoclonal antibody, clone B025 (AD51), Aff - Purified

Specifications

Product Data

• Clone Name: B025 (AD51)
• Applications: ELISA, IHC
• Recommended Dilution: ELISA.
  Immunohistochemistry on Frozen Sections.
  Immunohistochemistry on Paraffin Sections (Requires protein digestion pre-treatment of paraffin sections, e.g. trypsin or pronase, prior to staining).
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Adenovirus type 3 (ATCC strain VR847)
• Specificity: This Adenovirus antibody recognizes all Human Adenovirus serotypes; binding to the hexon polypeptide. No cross-reactions are known.
  Mouse anti adenovirus antibody, clone B025 (AD51) reacts with the adenovirus specific hexon polypeptide.
  
  
• Formulation: PBS
  State: Aff - Purified
  State: Liquid purified IgG fraction (> 90% IgG content by SDS-PAGE)
  Preservative: 0.09% Sodium Azide
• Concentration: 1.0 mg/ml
• Purification: Affinity Chromatography on Protein A
• Background: Adenoviruses are DNA viruses generally widespread in nature that are frequently the cause of acute upper respiratory tract infections (i.e. common colds). Forty-seven known serotypes have been isolated since they were first discovered in 1953 with 3 types known to cause gastroenteritis. Several types have oncogenic potential though most cause self-limiting febrile illnesses characterised by inflammation of conjunctivae and the respiratory tract. The virus can be isolated from the majority of tonsils/adenoids surgically removed, indicating latent infections. It is not known how long the virus can persist in the body, or whether it is capable of reactivation after long periods. In patients experiencing immunosuppression (e.g. AIDS) it can be reactivated causing disease.
  Hexon protein is a major coat protein of adenoviruses. Adenoviruses capsids have three principal protein components: the hexon, the penton, and the fiber. Hexon consists of three subunits together forming two major components of different morphological symmetry. A triangular top with three towers of density is superimposed on a more bulky pseudo hexagonal base. The symmetry of the top is in accord with the trimeric nature of hexon, but that of the base derives from the molecular function, which is to provide a densely packed impenetrable protective outer layer for the virion.