Tubulin (TUBA1B) (Tyr-Tubulin) Rat Monoclonal Antibody [Clone ID: YL1/2]

CAT#: SM2202P

Tubulin (TUBA1B) (Tyr-Tubulin) rat monoclonal antibody, clone YL1/2, Purified


USD 580.00

5 Days*

Size
    • 500 ug

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Specifications

Product Data
Clone Name YL1/2
Applications ELISA, IF, IHC, IP, R, WB
Recommended Dilution ELISA: 1/100-1/1000 (This antibody is routinely tested in ELISA on Tubulin) (3).
Immunoprecipitation. 
Radioimmunoassay. 
Immunofluorescence. 
Western blotting:
Suitable for use as a Loading Control. 
Immunohistochemistry on Frozen Sections.
Reactivities Birds, Mammalian, Yeast
Host Rat
Isotype IgG2a
Clonality Monoclonal
Immunogen Yeast Tubulin.
Spleen cells from immunised LOU rats were fused with cells of the Y3.Ag.1.2.3 rat myeloma cell line.
Specificity This antibody SM2202P recognizes the alpha subunit of Tubulin, specifically binding tyrosylated Tubulin (Tyr-Tubulin) (2). The epitope recognized by this antibody has been extensively studied and would appear to be a linear sequence requiring an aromatic residue at the C terminus, with the two adjacent amino acids being negatively charged (represented by Gly-Gly-Tyr in Tyr-Tubulin).
The antibody has been used in epitope tagging procedures to detect proteins tagged with a C-terminal Gly-Gly-Phe epitope. These sequence requirements have been reported to result in some cross-reactivity with other proteins in certain circumstances, including E. coli rec A and oxidized Actin (5).
Formulation PBS
State: Purified
State: Liquid purfied IgG fraction
Preservative: 0.09% Sodium Azide
Concentration 1.0 mg/ml
Purification Affinity Chromatography on Protein G from tissue culture supernatant
Gene Name Homo sapiens tubulin alpha 1b (TUBA1B)
Background Tubulin is the major building block of microtubules. This intracellular cylindrical filamentous structure is present in almost all eukaryotic cells. Microtubules function as structural and mobile elements in mitosis, intracellular transport, flagellar movement and in the cytoskeleton. Tubulin is a heterodimer which consists of alpha tubulin and beta tubulin.
Synonyms Tubulin alpha-1B chain, Tubulin alpha-ubiquitous chain, Alpha-tubulin ubiquitous, Tubulin K-alpha-1
Reference Data
Protein Families Druggable Genome
Protein Pathways Gap junction, Pathogenic Escherichia coli infection

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