CD34 Mouse Monoclonal Antibody [Clone ID: 1H6]

CAT#: SM2257F

CD34 mouse monoclonal antibody, clone 1H6, FITC


USD 560.00

5 Days*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name 1H6
Applications FC
Recommended Dilution Flow Cytometry: Use 10 µl of neat-1/10 diluted antibody to label 10e6 cells in 100 µl.
Reactivities Canine
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Canine CD34 fusion protein.
Specificity SM2257F is specific for Canine CD34, a cell surface antigen of approximately 110 kDa expressed by endothelial cells and haematopoietic stem cells.
Clone 1H6 is reported for use in CD34+ enrichment studies (4,5).
Formulation PBS, pH 7.4 containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer.
Label: FITC
State: Liquid purified IgG fraction.
Label: Fluorescein Isothiocyanate Isomer 1
Concentration 0.1 mg/ml
Purification Affinity Chromatography on Protein G.
Conjugation FITC
Gene Name -
Background The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence.
Synonyms Hematopoietic progenitor cell marker
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.