TNFSF18 / AITRL Rat Monoclonal Antibody [Clone ID: YGL386]

CAT#: SM2258PS

TNFSF18 / AITRL rat monoclonal antibody, clone YGL386, Purified

Specifications

Product Data

• Clone Name: YGL386
• Applications: FC
• Recommended Dilution: Flow Cytometry: 1/25 - 1/50; use 10 µl of the suggested working dilution to label 106 cells in 100 µl.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant mouse GITRL. Spleen cells from immunised DA rats were fused with cells of the Y3/Ag1.2.3 myeloma cell line.
• Specificity: This antibody recognises glucocorticoid-induced tumour necrosis factor receptor ligand (GITRL).
• Formulation: PBS, pH7.4 containing 0.09% Sodium Azide
  State: Purified
  State: Liquid purified IgG
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography on Protein G
• Background: GITRL is a 20 kD member of the tumour necrosis factor ligand superfamily, otherwise known as TNSF18. Mouse GITRL is predominantly expressed on immature and mature dendritic cells, macrophages and B cells. Expression of mouse GITRL can be transiently up regulated on these cells, following lipolysaccharide (LPS) stimulation, but protein expression is rapidly down modulated shortly after stimulation. Studies demonstrate that GITRL can neutralise the suppressive effects of CD4+CD25+ regulatory T cells and can also provide a co-stimulatory signal for both naive and primed T cells, suggesting a key role for GITRL in the regulation of T cell-mediated immunity.
• Synonyms: GITRL, TL6, AITRL, hGITRL