Itgam Mouse Monoclonal Antibody [Clone ID: WT.3]

CAT#: SM264F

Itgam mouse monoclonal antibody, clone WT.3, FITC


USD 415.00

In Stock*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name WT.3
Applications FC
Recommended Dilution Flow Cytometry: Use 10 µl of neat antibody to label 106 cells in 100 µl.
Reactivities Rat
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen FTL-43. Lymph node cells from immunised BALB/c mice were fused with cells from the PAI mouse myeloma cell line.
Specificity Clone WT.3 reacts with the rat beta 2 integrin, which is designated CD18.
The beta 2 integrin may be associated with the integrin alphaL, alphaX or alphaM subunits. 
The antibody  has been shown to inhibit homotypic aggregation of PHA blasts. 
It also blocks binding of rat lymphocytes to purified rat ICAM-1.
Formulation PBS containing 0.09% Sodium Azide and 1% Bovine Serum Albumin
Label: FITC
State: Liquid purified IgG fraction
Label: Fluorescein Isothiocyanate Isomer 1
Concentration 0.1 mg/ml
Purification Affinity chromatography on Protein A
Conjugation FITC
Background CD18 is an integrin. Integrins are integral cell surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA1, and combines with the alpha M chain to form the integrin Mac1. Integrins are known to participate in cell adhesion as well as cell surface mediated signalling. CD18 is expressed by most leucocytes. Defects in the CD18 gene result in leukocyte adhesion deficiency.
Synonyms Integrin beta-2, MFI7
Reference Data

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