CD34 Class III Mouse Monoclonal Antibody [Clone ID: 4H11]

CAT#: SM3018BT

CD34 Class III mouse monoclonal antibody, clone 4H11, Biotin


USD 270.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Clone Name 4H11
Applications FC
Recommended Dilution Indirect immunofluorescence analysis by Flow cytometry (1:200 as starting point).
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Permanent human cell line derived from peripheral leucocytes of a patient suffering from chronic myeloid leukaemia
Specificity This antibody reacts with Class III epitope on CD34 (Mucosialin), a 110-115 kDa monomeric transmembrane phosphoglycoprotein expressed on hematopoietic progenitors cells and on the most pluripotential stem cells; it is gradually lost on progenitor cells. The antibody 4H11[APG] completely blocks binding of Class II antibody QBEnd10 and Class III antibodies BIRMA K3 and 8G12 on KG1a cell line.
Formulation Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Label: Biotin
State: Liquid purified Ig fraction
Label: The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
Concentration lot specific
Conjugation Biotin
Storage Store the antibody undiluted at 2 - 8 °C. DO NOT FREEZE!
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens CD34 molecule (CD34), transcript variant 1
Background CD34 is a highly glycosylated monomeric 111-115 kDa surface protein, which is present on many stem cell populations. It is a well established stem cell marker, though its expression on human hematopoietic stem cells is reversible. CD34 probably serves as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions.
Synonyms Hematopoietic progenitor cell marker
Reference Data
Protein Families Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways Cell adhesion molecules (CAMs), Hematopoietic cell lineage

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.