CD41 (ITGA2B) Mouse Monoclonal Antibody [Clone ID: MEM-06]

CAT#: SM3021B

CD41 (ITGA2B) mouse monoclonal antibody, clone MEM-06, Biotin

Product Images

Surface staining of human platelets with anti-human CD41 (MEM-06) biotin, streptavidin-APC.

Specifications

Product Data

• Clone Name: MEM-06
• Applications: FC
• Recommended Dilution: Indirect immunofluorescence analysis by Flow Cytometry: 1:200 as starting dilution.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Leukocytes of patient suffering from LGL-type leukaemia
• Specificity: This antibody reacts with CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIba (heavy chain; 120 kDa) and GPIIbb (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
• Formulation: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
  Label: Biotin
  State: Liquid Ig fraction
  Label: Conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
• Concentration: lot specific
• Conjugation: Biotin
• Storage: Store the antibody undiluted at 2 - 8 °C. DO NOT FREEZE!
• Stability: Shelf life: one year from despatch.
• Gene Name: integrin subunit alpha 2b
• Database Link:
  Entrez Gene 3674 Human
• Background: CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, a and 23 kDa b, b) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.
• Synonyms: Integrin alpha-IIb, GP2B, ITGAB, GPalpha IIb