CD55 / DAF Mouse Monoclonal Antibody [Clone ID: MEM-118]

CAT#: SM3030B

CD55 / DAF mouse monoclonal antibody, clone MEM-118, Biotin

Product Images

Surface staining of human peripheral blood cells with anti-CD55 (MEM-118) biotin / streptavidin-APC.

Specifications

Product Data

• Clone Name: MEM-118
• Applications: FC
• Recommended Dilution: Immunofluorescence analysis by Flow Cytometry: 1/500 as a starting point.
• Reactivities: Human, Primate
• Host: Mouse
• Isotype: IgM
• Clonality: Monoclonal
• Immunogen: HPB-ALL human T cell line
• Specificity: The antibody recognizes an epitope in SCR4 domain of CD55 (Decay accelerating factor, DAF), a 60-70 kDa glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein. CD55 is widely expressed on hematopoietic and on many non-hematopoietic cells; it is weakly present on NK cells.
• Formulation: Tris buffered saline (TBS) with 15 mM sodium azide, approx. pH 8.0
  Label: Biotin
  State: Liquid purified Ig fraction
  Label: Conjugated with Biotin-LC-NHS under optimum conditions.
• Concentration: 1.0 mg/ml
• Conjugation: Biotin
• Background: CD55 (decay-accelerating factor, DAF) is a GPI-anchored membrane glycoprotein that protects autologous cells from classical and alternative pathway of complement cascade. Bidirectional interactions between CD55 and CD97 are involved in T cell regulation and CD55 can still regulate complement when bound to CD97. In tumours, besides protection agains complement, CD55 promotes neoangiogenesis, tumorigenesis, invasiveness and evasion of apoptosis.