LCK Mouse Monoclonal Antibody [Clone ID: LCK-01]

CAT#: SM3066P

LCK mouse monoclonal antibody, clone LCK-01, Purified


USD 250.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name LCK-01
Applications FC, IF, IP, WB
Recommended Dilution Flow Cytometry.
Immunoprecipitation.
Western Blotting.
Immunocytochemistry.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Peptide corresponding to amino acids 22-36 in the sequence of Human Lck
Specificity The antibody recognizes defined epitope (aa 22-36) of Lck, a 56 kDa Src-family protein tyrosine kinase.
Negative Species: Mouse.
Formulation Phosphate Buffered Saline (PBS), pH~7.4 with 15 mM Sodium Azide as preservative.
State: Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE).
Concentration lot specific
Purification Affinity Chromatography on Protein A.
Storage Store undiluted at 2-8°C.
DO NOT FREEZE!
Stability Shelf life: one year from despatch.
Background Lck is a Src-family tyrosine kinase, which is essential for signaling through the T-cell receptor (TCR) complex. Upon TCR triggering, Lck phosphorylates the ITAM motives in its z subunits, establishing binding sites for the SH2 domains of the tyrosine kinase ZAP70, which is also phosphorylated by Lck and thereby activated to generate subsequent signaling platforms by phosphorylation of adaptor LAT. Whereas the majority of Lck is localized to the plasma membrane, there is also a significant fraction associated with the Golgi apparatus, which may contribute to Raf activation under conditions of weak stimulation through the TCR. Lck is also involved in the regulation of apoptosis induced by various stimuli, but not by the death receptors.
Synonyms p56-LCK, LSK
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.