SIT (SIT1) Mouse Monoclonal Antibody [Clone ID: SIT-01]

CAT#: SM3074R

SIT (SIT1) mouse monoclonal antibody, clone SIT-01, PE


USD 385.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Clone Name SIT-01
Applications FC
Recommended Dilution Flow cytometry (1/50, intracellular staining).
Reactivities Human, Mouse
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Bacterially produced recombinant intracellular fragment of human SIT
Specificity The antibody reacts with SHP2-interacting transmembrane adaptor protein (SIT) expressed exclusively in lymphoid organs.
Formulation Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent
Label: PE
State: Liquid purified Ig fraction
Label: Conjugated with R-Phycoerythrin under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Concentration 0.1 mg/ml
Conjugation PE
Gene Name Homo sapiens signaling threshold regulating transmembrane adaptor 1 (SIT1)
Background SIT (SHP2-interacting transmembrane adaptor protein) is expressed exclusively in lymphoid organs and acts either as a positive or as a negative regulatory element in T cell activation and in T cell development. Binding to Grb2 plays a pivotal role in signal transduction. Hubener et al. (2001) determined that the SIT gene contains 5 exons and spans 1.8 kb of genomic DNA. The SIT promoter demonstrated strong transcriptional activity and potential binding sites for both ubiquitous and lymphoid-specific transcription factors.
Synonyms 40; gp30; MGC125908; MGC125909; MGC125910; RP11-331F9.5; SIT
Reference Data
Protein Families Transmembrane

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.