CD52 Mouse Monoclonal Antibody [Clone ID: HI186]
Specifications
Product Data | |
Clone Name | HI186 |
Applications | FC, IHC |
Recommended Dilution | Flow Cytometry: 2 µg/ml. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin-Embedded Sections. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG2b |
Clonality | Monoclonal |
Immunogen | Human tonsil |
Specificity | This antibody Clone HI186 reacts with CD52, a 21-28 kDa glycoprotein containing a large N-linked carbohydrate moiety. Mature CD52 molecule is actually much smaller (approx. 8-9 kDa). |
Formulation | PBS, pH~7.4 State: Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) Preservative: 15 mM Sodium Azide |
Concentration | lot specific |
Purification | Protein A Chromatography |
Storage | Store undiluted at 2-8°C. DO NOT FREEZE! |
Stability | Shelf life: one year from despatch. |
Database Link | |
Background | CD52 (CAMPATH-1, HE5) is a highly glycosylated GPI-anchored 21-28 kDa glycopeptide which is present at high levels on lymphocytes, macrophages, epithelial cells of male reproductive tract and mature sperm. Its 12-amino acid beckbone carries a complex N-linked carbohydrate moiety, which differs between sperm and leukocyte CD52, as well as the GPI anchor does. CD52 can be acquired by sperm cells from seminal plasma, where it is released by epithelial cells. Although CD52 is not an essential T-cell costimulator, its triggering results in activation of normal human T cells. CD52 is a very good target for antibody/complement-mediated cell lysis. |
Synonyms | HE5, CDw52 |
Reference Data |
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