CD8A Mouse Monoclonal Antibody [Clone ID: MEM-31]

CAT#: SM3102F

CD8A mouse monoclonal antibody, clone MEM-31, FITC


USD 270.00

2 Weeks*

Size
    • 100 Tests

Product Images

Other products for "CD8A"

Specifications

Product Data
Clone Name MEM-31
Applications FC
Recommended Dilution Flow Cytometry: Human blood cells using 20 µl reagent / 100 µl whole blood or 106 cells in a suspension.
Does not work in Immunohistochemistry on formalin fixed cells or Western blot.
Reactivities Human
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Crude thymus membrane fraction
Specificity The antibody recognizes a conformationally-dependent epitope of CD8 antigen.
Formulation Phosphate buffered saline (PBS) containing 15 mM Sodium Azide
Label: FITC
State: Liquid purified Ig fraction
Label: Conjugated with Fluorescein isothiocyanate under optimum conditions. The reagent is free of unconjugated and adjusted for direct use.
Conjugation FITC
Storage Store the antibody at 2-8°C.
DO NOT FREEZE.
This product is photosensitive and should be protected from light.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens CD8a molecule (CD8A), transcript variant 1
Background The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as ab heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as aa homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. Regulation of CD8b level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 a-b but not a-a dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8, thereby affecting the functional diversity of the TCR signaling.
Synonyms CD8 alpha chain, CD8A, MAL
Reference Data
Protein Families Adult stem cells, Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane
Protein Pathways Antigen processing and presentation, Cell adhesion molecules (CAMs), Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.