CD18 (ITGB2) Mouse Monoclonal Antibody [Clone ID: MEM-48]

CAT#: SM3103F

CD18 (ITGB2) mouse monoclonal antibody, clone MEM-48, FITC


USD 270.00

2 Weeks*

Size
    • 100 Tests

Product Images

Specifications

Product Data
Clone Name MEM-48
Applications FC, IHC, WB
Recommended Dilution Flow Cytometry analysis of human blood cells using 20 µl reagent / 100 µl whole blood.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Leucocytes of a patient suffering from a LGL-type leukaemia
Specificity The antibody recognizes an epitope involving residues 534-546 in cysteine-rich repeat 3 of the CD18 antigen (Integrin beta2 chain).
Formulation Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent
Label: FITC
State: Liquid purified Ig fraction
Label: Conjugated with Fluorescein isothiocyanate under optimum conditions. The reagent is free of unconjugated and adjusted for direct use
Conjugation FITC
Storage Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Stability Shelf life: one year from despatch.
Background CD18 is a 90-95 kDa type I transmembrane protein expressed on all leukocytes.
CD18, integrin b2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (b2) integrins: aLb2 (CD11a/CD18, LFA-1), aMb2 (CD11b/CD18, Mac-1, CR3), aXb2 (CD11c/CD18) and aDb2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1; severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis.
Synonyms Integrin beta-2, MFI7
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.