NTAL (LAT2) Mouse Monoclonal Antibody [Clone ID: NAP-07]

CAT#: SM3122RP

NTAL (LAT2) mouse monoclonal antibody, clone NAP-07, PE

Product Images

Subcellular localization of NTAL by confocal microscopy in THP-1 human acute monocytic leukemia cell line. THP-1 cells were permeabilized and immunostained using anti-NTAL (NAP-07; green). Nuclei are vizualized by propidium iodide (red).

Specifications

Product Data

• Clone Name: NAP-07
• Applications: FC, IF
• Recommended Dilution: Flow cytometry: 1:30.
• Reactivities: Human, Mouse
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Recombinant cytoplasmic domain (aa 91-243) of human NTAL
• Specificity: This antibody reacts with Non-T cell activation linker (NTAL), also known as LAB (linker of activated B cells), a 25 - 30 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B lymphocytes, NK cells and myeloid cells.
• Formulation: Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent
  Label: PE
  State: Liquid purified Ig fraction
  Label: Conjugated with R-Phycoerythrin under optimum conditions. The conjugate is purified by size-exclusion chromatography
• Concentration: lot specific
• Conjugation: PE
• Storage: Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens linker for activation of T-cells family member 2 (LAT2), transcript variant 3
• Database Link:
  Entrez Gene 56743 MouseEntrez Gene 7462 Human
• Background: NTAL (Non-T cell activation linker), also known as LAB (Linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.
• Synonyms: LAB, NTAL, WBS15, WBSCR5, HSPC046

Reference Data

• Protein Families: Transmembrane