DR4 (TNFRSF10A) Mouse Monoclonal Antibody [Clone ID: DR-4-02]

CAT#: SM3131AC

DR4 (TNFRSF10A) mouse monoclonal antibody, clone DR-4-02, APC


USD 425.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name DR-4-02
Applications FC, IF
Recommended Dilution Flow cytometry.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1
Specificity This antibody recognizes TRAIL-R1 (DR4), a human death receptor 4 (468 amino acids) expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived cell lines.
Formulation Phosphate buffered saline (PBS)
Label: APC
State: Liquid purified Ig fraction
Stabilizer: 0.2% (w/v) high-grade protease free BSA
Preservative: 15 mM Sodium Azide
Label: Conjugated with cross-linked Allophycocyanin (APC) under optimum conditions.
The conjugate is purified by size-exclusion chromatography.
Concentration 0.1 mg/ml
Purification The conjugate is purified by size-exclusion chromatography
Conjugation APC
Gene Name tumor necrosis factor receptor superfamily member 10a
Background TRAIL-R1 (CD261, DR4) is a type I transmembrane protein, also called TRAIL receptor 1. The ligand for this DR4 death receptor has been identified and termed TRAIL, which is a member of the TNF family. DR4, as many other receptors (Fas, TNFR1, etc.), mediates apoptosis and NF kappaB activation in many cells and tissues. Apoptosis, a programmed cell death, is a operating process in normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by coupled of certain cytokines (TNF family - TNF, Fas ligand) and their death domain containing receptors (TNFR1, Fas receptor).
Synonyms APO2, DR4, Death receptor 4, TRAIL receptor 1, TRAIL-R1, TNFRSF10A
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.