IL2 Receptor alpha (IL2RA) Mouse Monoclonal Antibody [Clone ID: MEM-140]
Specifications
Product Data | |
Clone Name | MEM-140 |
Applications | FC, IP |
Recommended Dilution | Flow Cytometry: 1:200 (starting point). |
Reactivities | Human |
Host | Mouse |
Isotype | IgM |
Clonality | Monoclonal |
Immunogen | PHA-activated peripheral blood leucocytes |
Specificity | This antibody reacts with CD25 (Interleukin-2 receptor a chain), a 55 kDa type I transmembrane glycoprotein expressed on activated B and T lymphocytes, activated monocytes/macrophages and on CD4+ T lymphocytes (T regulatory cells); it is lost on resting B and T lymphocytes. |
Formulation | Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 Label: Biotin State: Liquid purified Ig fraction Label: Conjugated with -LC-NHS under optimum conditions. The reagent is free of unconjugated biotin |
Concentration | lot specific |
Conjugation | Biotin |
Storage | Store the antibody undiluted at 2 - 8 °C. DO NOT FREEZE! |
Stability | Shelf life: one year from despatch. |
Database Link | |
Background | CD25 (IL2Ralpha, Tac) is a ligand-binding alpha subunit of interleukin 2 receptor (IL2R). Together with beta and gamma subunit CD25 constitues the high affinity IL2R, whereas CD25 alone serves as the low affinity IL2R. CD25 expression rapidly increases upon T cell activation. The 55 kDa CD25 molecule is enzymatically cleaved and shed from the cell surface as a soluble 45 kDa s-Tac, whose concentration in serum can be used as a marker of T cell activation. Expression of CD25 indicates the neoplastic phenotype of mast cells. Humanized anti CD25 antibodies represent a useful tool to reduce the incidence of allograft rejection as well as the severity of graft versus host reaction, and radioimmunoconjugates of anti-CD25 antibodies can be used against CD25 expressing lymphomas. |
Synonyms | Interleukin-2 receptor alpha chain, IL-2 receptor alpha subunit, IL-2-RA, IL2-RA, p55, TAC antigen |
Reference Data |
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