MHC Class I (monomorphic) Mouse Monoclonal Antibody [Clone ID: CVS22]

CAT#: SM504PS

MHC Class I (monomorphic) mouse monoclonal antibody, clone CVS22, Purified

Product Images

Staining of equine peripheral blood lymphocytes with MHC Class I antibody Cat.-No. SM504PS, followed by FITC conjugated secondary antibody.

Specifications

Product Data

• Clone Name: CVS22
• Applications: FC, IHC, IP
• Recommended Dilution: Flow cytometry: 1/25-1/200, use 10µl of this working dilution to label 10e6 cells in 100µl.
  Immunohistochemistry on frozen sections.
  Immunoprecipitation.
• Reactivities: Equine
• Host: Mouse
• Isotype: IgG2a
• Clonality: Monoclonal
• Immunogen: Equine leucocytes
• Specificity: All tissues
• Formulation: PBS containing 0.09% Sodium azide
  State: Purified
  State: Liquid purified IgG
• Concentration: 1.0 mg/ml
• Purification: Affinity chromatography on Protein G
• Background: MHC Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. MHC class I antigens are heterodimers consisting of one alpha chain (44kDa) with beta 2 microglobulin (11.5 kDa). The antigen is expressed by all somatic cells at varying levels. MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. Fibroblasts or neurons however only show a low level of antigen.
• Synonyms: MHC Class 1, HLA Class 1