Von Willebrand Factor (VWF) Sheep Polyclonal Antibody

CAT#: SP1313P

Von Willebrand Factor (VWF) sheep polyclonal antibody, Purified


USD 340.00

5 Days*

Size
    • 1 ml

Product Images

Specifications

Product Data
Applications ELISA, FC, ID, IF, IHC
Recommended Dilution Immunodiffusion: Neat.
ELISA.
Flow Cytometry. 
Immunofluorescence.

Immunohistochemistry on Frozen Sections: The epitope recognized by this antibody is reported to be sensitive to formaldehyde fixation and tissue processing. The use of acetone fixation is recommended for frozen sections. 
Recommended Positive Control: Tonsil. 
Does not work on paraffin sections!.
Reactivities Human
Host Sheep
Isotype IgG
Clonality Polyclonal
Immunogen Purified Human von Willebrand factor.
Specificity This antibody recognizes Human Willebrand factor VIII. Other species not tested.
Formulation Glycine buffered saline pH 7.4, 0.01% Benzamidine, 0.1% EACA and 1mM EDTA
State: Purified
State: Liquid purified IgG fraction from Serum
Preservative: 0.09% Sodium Azide
Purification Ion Exchange Chromatography
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Background Von Willebrand Factor (VWF) was previously known as Factor VIII related antigenis. VWF is synthesized exclusively by endothelial cells and megakaryocytes, and stored in the intracellular granules or constitutively secreted into plasma. This glycoprotein functions as both an antihemophilic factor carrier and a platelet vessel wall mediator in the blood coagulation system. Important in the maintenance of homeostasis, it participates in platelet vessel wall interactions by forming a noncovalent complex with coagulation factor VIII at the site of vascular injury. The Von Willebrand factor has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. Mutations in this gene or deficiencies in this protein result in Von Willebrand's disease. VWD is characterized by frequent bleeding (gingival, minor skin quantitative lacerations, menorrhagia, etc.).
Synonyms vWF, von Willebrand antigen 2, von Willebrand antigen II, F8VWF, Factor VIII Related Antigen
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.