IFNB Rabbit Polyclonal Antibody

CAT#: SP2137A

IFNB rabbit polyclonal antibody, Azide Free

Specifications

Product Data

• Applications: FN, IP, WB
• Recommended Dilution: Immunoprecipitation.
  Western Blot: This antibody detects a band of approximately 20 kDa.
  Funktional Assays.
• Reactivities: Chicken
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Recombinant chicken Interferon Beta
• Specificity: This antibody recognizes Interferon beta (chIFN-beta). This antibody does not cross react with IFN gamma. This antiserum neutralizes chIFN-beta and can be used to discriminate IFN alpha and IFN beta bioactivities.
• Formulation: PBS
  State: Azide Free
  State: Liquid purified IgG
• Concentration: 0.5 mg/ml
• Purification: Affinity chromatography on protein G
• Database Link:
  Entrez Gene 554219 Chicken
• Background: Reports suggest that chIFN exhibits properties similar to mammalian IFN type I (IFNI). Functional studies revealed the presence of two distantly related IFNI genes, designated as IFN alpha and IFN beta, found on chicken chromosome Z. The serological distinction between these two IFNs has been verified using neutralisation assays, and there is evidence that the antiviral activity of chIFN-beta is approximately tenfold less compared to chIFN-alpha. This would suggest that chIFNbeta might have a different physiological role, though chIFN-beta is expressed strongly in virus-infected cells.
• Synonyms: IFN-beta, IFNB1, IFB, Fibroblast interferon