Collagen I (COL1A1) Goat Polyclonal Antibody

CAT#: SP2175B

Collagen I (COL1A1) goat polyclonal antibody, Biotin

Specifications

Product Data

• Applications: ELISA
• Recommended Dilution: ELISA: 1:200 - 1:2000.
• Reactivities: Human
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Human type 1 collagen
• Specificity: This antibody recognises Type 1 collagen.
  This antibody has been cross-adsorbed against collagen types II, III, IV, V and VI.
  Results from ELISA demonstrate less than 10% cross-reactivity with other collagen types.
• Formulation: PBS containing 0.09% Sodium Azide
  Label: Biotin
  State: Liquid purified IgG
• Concentration: lot specific
• Purification: Affinity chromatography
• Conjugation: Biotin
• Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens collagen type I alpha 1 chain (COL1A1)
• Database Link:
  Entrez Gene 1277 Human
• Background: Collagens are highly conserved throughout evolution and are characterised by an uninterrupted "Glycine X Y" triplet repeat that is a necessary part of the triple helical structure. Type I collagen (95 kDa) is found in bone, cornea, skin and tendon. Mutations in the encoding gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for Platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor.
• Synonyms: COL1A1, COL1A2, Alpha-1 type I collagen, Alpha-2 type I collagen

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: ECM-receptor interaction, Focal adhesion