Collagen I (COL1A1) Goat Polyclonal Antibody

CAT#: SP2175P

Collagen I (COL1A1) goat polyclonal antibody, Aff - Purified

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: Immunohistochemistry on Frozen Sections (1/10-1/20).
  ELISA.
• Reactivities: Human
• Host: Goat
• Clonality: Polyclonal
• Immunogen: Human type 1 Collagen
• Specificity: This antibody recognizes Human Type 1 Collagen.
  It has been cross-adsorbed against Collagen types II, III, IV, V and VI.
  Results from ELISA demonstrate < 10% cross-reactivity with other Collagen types.
• Formulation: Borate buffered saline
  State: Aff - Purified
  State: Liquid purified Ig fraction
  Stabilizer: None
  Preservative: None
• Concentration: lot specific
• Purification: Affinity Chromatography
• Storage: Upon receipt, store undiluted (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens collagen type I alpha 1 chain (COL1A1)
• Database Link:
  Entrez Gene 1277 Human
• Background: Collagens are highly conserved throughout evolution and are characterised by an uninterrupted "Glycine X Y" triplet repeat that is a necessary part of the triple helical structure. Type I collagen (95 kDa) is found in bone, cornea, skin and tendon. Mutations in the encoding gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for Platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor.
• Synonyms: COL1A1, COL1A2, Alpha-1 type I collagen, Alpha-2 type I collagen

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: ECM-receptor interaction, Focal adhesion