ROR gamma (RORC) (Modulating Domain) Rabbit Polyclonal Antibody

CAT#: SP4490P

ROR gamma (RORC) (Modulating Domain) rabbit polyclonal antibody, Aff - Purified

Product Images

Immunohistochemistry staining of human thymus (Formalin-fixed, Paraffin-embedded tissue after heat-induced antigen retrieval) using ROR-gamma / RORC antibody.

Specifications

Product Data

• Applications: ELISA, IHC
• Recommended Dilution: ELISA.
  Immunohistochemistry on Paraffin Sections: 10 - 15 µg/ml.
• Reactivities: Human
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic 14 amino acid peptide from modulating domain of human ROR-gamma
• Specificity: Reacts with modulating domain of ROR-gamma / RORC.
• Formulation: PBS containing 0.09% Sodium azide
  State: Aff - Purified
  State: Liquid Ig fraction
• Concentration: lot specific
• Purification: Immunoaffinity chromatography
• Storage:

  Store undiluted at 2-8°C for one month or (in aliquots) at -20°C to -80°C for longer.
  Avoid repeated freezing and thawing.

• Stability: Shelf life: one year from despatch.

• Gene Name: Homo sapiens RAR related orphan receptor C (RORC), transcript variant 2
• Database Link:
  Entrez Gene 6097 Human
• Background: ROR-gamma, a NR1 thyroid hormone-like receptor, has been shown to affect thymopoiesis, bone metabolism, T-cell apoptosis, and lymphoid organogenesis. ROR gamma has been shown to promote thymocyte survival by activating the expression of the antiapoptotic protein Bcl-x(L). ROR gamma is also required for the development of lymph nodes and Peyer's patches. It has been shown that ROR gamma t, a thymus-specific isoform of ROR gamma from mouse, inhibits Fas ligand expression and cytokine secretion in immature thymocytes. ROR gamma binds as a monomer to response elements composed of a single core motif, GGTCA, preceded by a 6 bp AT-rich sequence.
  ROR-gamma expression has been documented in mouse thymus, adipose, bone, skeletal muscle, liver, and kidney, and in human skeletal muscle. ESTs have been isolated from human tissue libraries, including cancerous head/neck, germ cell, and prostate, and normal colon, head/neck, lung, liver/spleen, and pancreas.
• Synonyms: Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, NR1F3, RORG, RZRG

Reference Data

• Protein Families: Druggable Genome, Transcription Factors