Caveolin 1 (CAV1) Rabbit Monoclonal Antibody [Clone ID: E249]

CAT#: TA300391

Rabbit Monoclonal Antibody against CAV1 (Clone E249)

Product Images

Western blot - Caveolin 1 antibody [E249]; Anti-Caveolin 1 antibody [E249] + A431 cell lysate.Predicted band size : 20 kDa.Observed band size : 23 kDa.Additional bands at : 22 kDa. We are unsure as to the identity of these extra bands.

• 

  Immunohistochemistry (Paraffin-embedded sections) - Anti-Caveolin 1 antibody [E249]; Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human urinary bladder tissue, staining Caveolin 1 with TA300391 at 1/250 dilution.

• 

  Immunohistochemistry (Paraffin-embedded sections) - Anti-Caveolin 1 antibody [E249]; Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human lung tissue, staining Caveolin 1 with TA300391 at 1/250ug/ml.

• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Caveolin 1 antibody [E249]; Immunohistochemical analysis of developing Human lung tissue, staining Caveolin 1 with TA300391 at 1/250 dilution.

Specifications

Product Data

• Clone Name: E249
• Applications: IHC, WB
• Recommended Dilution: ICC/IF: Use at an assay dependent dilution; IHC-P: 1:250; ICC: 1:100; WB: 1:1000 - 1:10000
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG fraction
• Clonality: Monoclonal
• Immunogen: A synthetic peptide corresponding to residues near C-terminus of human Caveolin-1 was used as immunogen. The antibody should recognize both alpha and beta form of Caveolin-1.
• Formulation: PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• Purification: IgG fraction
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: caveolin 1
• Database Link:
  NP_001744
  Entrez Gene 25404 RatEntrez Gene 857 Human
  UniProt ID Q03135
• Background: Caveolins make up a family of proteins that are principal structural components of hairpin-like domains in the plasma membrane (1). It is believed that caveolins serve as scaffolding proteins for the integration of signal transduction. Three members of caveolins (caveolin-1, -2 and -3) have been identified, possessing different tissue distributions (2). Caveolins interact with multiple signaling molecules, such as the G-protein alpha subunit (1), tyrosine kinase receptors, PKCs, Src family tyrosine kinases and eNOS (2,3). Caveolin-1 has been implicated in the pathogenesis of mammary epithelial cell hyperplasia (4).
• Synonyms: BSCL3; CGL3; LCCNS; MSTP085; PPH3; VIP21
• Note: Is unsuitable for Flow Cyt or IP.

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Focal adhesion, Viral myocarditis