alpha 1 Fetoprotein (AFP) Rabbit Monoclonal Antibody [Clone ID: EP1016Y]

CAT#: TA300729

Rabbit Monoclonal Antibody against AFP (Clone EP1016Y)

Product Images

Western blot - alpha 1 Fetoprotein antibody [EP1016Y]; Anti-alpha 1 Fetoprotein [EP1016Y] antibody at 1/500000 dilution + HepG2 cell lysate at 10 ug.Secondary.goat anti-rabbit HRP at 1/2000 dilution.Predicted band size : 69 kDa.Observed band size : 69 kDa.

Specifications

Product Data

• Clone Name: EP1016Y
• Applications: WB
• Recommended Dilution: WB: 1:500000; IP: 1:50
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide corresponding to residues near the N-term of human AFP was used as an immunogen.
• Formulation: PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• Purification: Tissue culture supernatant
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 69 kDa
• Gene Name: alpha fetoprotein
• Database Link:
  NP_001125
  Entrez Gene 174 Human
  UniProt ID P02771
• Background: Alpha-fetoprotein (AFP) is a serum glycoprotein protein produced in the liver or yolk sac of fetal staged mammals. AFP synthesis is minimal after birth and trace amount is expressed in the adult liver (1). AFP gene expression is regulated by the interactions between steroid hormone receptors and transcriptional factors in separate signal transduction pathways (2). AFP functions as a binding and transporting ligand and cell growth regulator. Elevated expression level of AFP has been implicated in colorectal, ovarian, pancreatic, testicular, and certain liver cancers. High levels of AFP are also seen in some diseases such as hepatitis and colitis. AFP is used as a screening marker for fetal abnormalities in pregnant women such as Down syndrome. Recently, AFP has been introduced as an anti-cancer drugs-ligand carrier, transporting drugs to target tumor cells, increasing anti-tumor efficiency (3).
• Synonyms: AFPD; FETA; HPAFP
• Note: Is unsuitable for Flow Cyt,ICC,IHC-Fr or IHC-P.

Reference Data

• Protein Families: Druggable Genome, Secreted Protein