Prostaglandin D Synthase (PTGDS) Rabbit Polyclonal Antibody

CAT#: TA301421

Rabbit Polyclonal Antibody against PTGDS

Product Images

Western Blot: Prostaglandin D Synthase/Lipocalin Antibody TA301421 - Detection of PTGDS in human brain lysates (NB820-59177) using TA301421 at 0.5 and 2.0 ug/ml.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 2 ug/ml
• Reactivities: Human, Feline, Bovine, Rabbit, Dog, Rat, Mouse, Primate
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The epitope recognized by this antibody maps to region within residue 120-190 of human PTGDS. [Swiss-Prot# P41222]
• Formulation: PBS + 30% glycerol and 0.1% sodium azide
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: prostaglandin D2 synthase
• Database Link:
  NP_000945
  Entrez Gene 19215 MouseEntrez Gene 25526 RatEntrez Gene 403740 DogEntrez Gene 5730 Human
  UniProt ID P41222
• Background: The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. PTGDS has also been implicated in the development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement (NREM) sleep. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. PTGDS is the most abundant protein in the cerebral spinal fluid and recent evidence suggests that PTGDS acts as a Beta-Amyloid chaperone and may have a role in the deposition of Ab plaques in Alzheimer? disease.
• Synonyms: L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2

Reference Data

• Protein Pathways: Arachidonic acid metabolism, Metabolic pathways