HSP27 (HSPB1) Rabbit Polyclonal Antibody

CAT#: TA301439

Rabbit Polyclonal Antibody against Crystallin AB

Product Images

Immunocytochemistry/Immunofluorescence: AlphaB Crystallin/CRYAB Antibody TA301439 - CRYAB antibody was tested in SHSH5Y cells with DyLight488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).

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  Western Blot: AlphaB Crystallin/CRYAB Antibody TA301439 - Detection of CryAB using NB 100-2519 (0.5ug/ml). Lane 1: Human skeletal muscle Lane 2: Mouse skeletal muscle.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 0.5-1.0 ug/ml, Immunocytochemistry/ Immunofluorescence: 1:50 - 1:150
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide made to an internal region of the human Crystallin AB protein (within residues 100-175). [Swiss-Prot P02511]
• Formulation: Tris-citrate/phosphate (pH 7-8) and 0.1% sodium azide
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: heat shock protein family B (small) member 1
• Database Link:
  NP_001531
  Entrez Gene 15507 MouseEntrez Gene 3315 Human
  UniProt ID P04792
• Background: Crystallin AB (CryAB) is a developmentally regulated small heat shock protein known to protect cells from stress damage. It may also play an important role in the Golgi reorganization during cell division. CryAB is known to be associated with a number of neurodegenerative pathologies such as Alzheimer disease amd multiple sclerosis. As well, it has been found to be expressed in breast tumors of patients with shorter survival, suggesting that it may be a useful marker in identifying aggressive breast cancer.
• Synonyms: CMT2F; HEL-S-102; HMN2B; HS.76067; Hsp25; HSP27; HSP28; SRP27

Reference Data

• Protein Pathways: MAPK signaling pathway, VEGF signaling pathway