APE1 (APEX1) Rabbit Polyclonal Antibody
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Other products for "APE1"
Specifications
Product Data | |
Applications | IHC, WB |
Recommended Dilution | Chromatin Immunoprecipitation (ChIP): 1:10-1:500, Immunohistochemistry: 1:100, Immunocytochemistry/ Immunofluorescence: 1:50-1:200, Immunoprecipitation: 7 ug/ml, Western Blot: 1:1000, Immunohistochemistry-Paraffin: 1:100, Immunohistochemistry-Frozen: 1:100, Simple Western: 1:12.5, Flow Cytometry, Immunohistochemistry Free-Floating, Block/Neutralize |
Reactivities | Human, Mouse, Rat |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | Affinity purified human Apurinic/Apyrimidinic Endonuclease (APE/ref-1) fusion protein. |
Formulation | Tris-glycine, 150mM NaCl and 0.05% sodium azide |
Purification | Affinity purified |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | apurinic/apyrimidinic endodeoxyribonuclease 1 |
Database Link | |
Background | The mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is responsible for the repair of AP sites in DNA. In addition, this enzyme has been shown to function as a redox factor facilitating the DNA binding capability of FOS, JUN, NfkB, HIF-1a as well as other transcription factors. Recently, APE has also been shown to control p53 activity through redox alteration. APE is also linked to apoptosis, associated with thioredoxin, and altered levels of APE have been found in some cancers. APE appears to form a unique link between the DNA base excision pathway, oxidative signaling, transcription regulation, cancer and cell-cycle control. |
Synonyms | APE; APE1; APEN; APEX; APX; HAP1; REF1 |
Reference Data | |
Protein Families | Druggable Genome, Stem cell - Pluripotency, Transcription Factors |
Protein Pathways | Base excision repair |
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