APE1 (APEX1) Rabbit Polyclonal Antibody

CAT#: TA301441

Rabbit Polyclonal Antibody against APE1


USD 479.00

In Stock*

Size
    • 100 ul

Frequently bought together (2)
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Specifications

Product Data
Applications IHC, WB
Recommended Dilution Chromatin Immunoprecipitation (ChIP): 1:10-1:500, Immunohistochemistry: 1:100, Immunocytochemistry/ Immunofluorescence: 1:50-1:200, Immunoprecipitation: 7 ug/ml, Western Blot: 1:1000, Immunohistochemistry-Paraffin: 1:100, Immunohistochemistry-Frozen: 1:100, Simple Western: 1:12.5, Flow Cytometry, Immunohistochemistry Free-Floating, Block/Neutralize
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Affinity purified human Apurinic/Apyrimidinic Endonuclease (APE/ref-1) fusion protein.
Formulation Tris-glycine, 150mM NaCl and 0.05% sodium azide
Purification Affinity purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name apurinic/apyrimidinic endodeoxyribonuclease 1
Background The mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is responsible for the repair of AP sites in DNA. In addition, this enzyme has been shown to function as a redox factor facilitating the DNA binding capability of FOS, JUN, NfkB, HIF-1a as well as other transcription factors. Recently, APE has also been shown to control p53 activity through redox alteration. APE is also linked to apoptosis, associated with thioredoxin, and altered levels of APE have been found in some cancers. APE appears to form a unique link between the DNA base excision pathway, oxidative signaling, transcription regulation, cancer and cell-cycle control.
Synonyms APE; APE1; APEN; APEX; APX; HAP1; REF1
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency, Transcription Factors
Protein Pathways Base excision repair

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