HIF1 beta (ARNT) Rabbit Polyclonal Antibody

CAT#: TA301442

Rabbit Polyclonal Antibody against HIF-1 beta


USD 512.00

In Stock*

Size
    • 100 ul

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Specifications

Product Data
Applications IHC, WB
Recommended Dilution Immunohistochemistry: 1:150, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation: 1:10-1:500, Western Blot: 1:2000, Immunohistochemistry-Paraffin: 1:150, Simple Western: 1:1000, Gel Supershift Assay, Chromatin Immunoprecipitation (ChIP): 1:10-1:500, Immunoblotting
Reactivities Human, Bovine, Mouse, Rat, Sheep, Ferret
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Fusion protein to human HIF-1 beta. Containing a.a. 496-789.
Formulation 0.02% sodium azide
Purification Whole antisera
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name aryl hydrocarbon receptor nuclear translocator
Background Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis. This occurs as a posttranslational modification by prolyl hydroxylation. HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits. Both subunits are constantly translated. However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes. Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity. Therefore, the concentration of HIF-1 alpha increases in the cell. In contrast, HIF-1 beta remains stable under either condition. HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products. (1,5,6)
Synonyms bHLHe2; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; TANGO
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Pathways in cancer, Renal cell carcinoma

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