HIF1 beta (ARNT) Mouse Monoclonal Antibody [Clone ID: H1beta234]

CAT#: TA301443

Mouse Monoclonal Antibody against HIF-1 Beta (H1beta234)


USD 479.00

5 Days*

Size
    • 100 ul

Product Images

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Specifications

Product Data
Clone Name H1beta234
Applications IHC, WB
Recommended Dilution Western Blot: 1:500, Chromatin Immunoprecipitation (ChIP): 1:10-1:500, Gel Super Shift Assays, Immunocytochemistry/ Immunofluorescence, Chromatin Immunoprecipitation Sequencing, Immunohistochemistry: 1:100, Immunohistochemistry-Paraffin: 1:100, Immunoprecipitation, Immunoblotting: 1:100 - 1:2000
Reactivities Human, Bovine, Sheep, Mouse, Rat, Ferret
Host Mouse
Isotype IgG1, kappa
Clonality Monoclonal
Immunogen Fusion protein containing amino acids 496-789 of human HIF-1 beta.
Formulation PBS and 0.05% sodium azide
Concentration lot specific
Purification protein G purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name aryl hydrocarbon receptor nuclear translocator
Background Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease, and chronic obstructive pulmonary disease. HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis. This occurs as a posttranslational modification by prolyl hydroxylation. HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits. Both subunits are constantly translated. However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes. Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity. Therefore, the concentration of HIF-1 alpha increases in the cell. In contrast, HIF-1 beta remains stable under either condition. HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products.
Synonyms bHLHe2; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; TANGO
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Pathways in cancer, Renal cell carcinoma

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.