ATG5 Rabbit Polyclonal Antibody

CAT#: TA301481

Rabbit Polyclonal Antibody against ATG5


USD 479.00

2 Weeks*

Size
    • 100 ul

Frequently bought together (3)
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Specifications

Product Data
Applications IHC, WB
Recommended Dilution Radioimmunoassay, ELISA, Immunoblotting, Knockout Validated, Knockdown Validated, Electron Microscopy, Flow Cytometry, Western Blot: 1:500, Simple Western: 1:50, Immunocytochemistry/ Immunofluorescence: 1:250, Immunohistochemistry: 1:400, Immunohistochemistry-Paraffin: 1:400, Immunoprecipitation: 1:10 - 1:500, Proximity Ligation Assay
Reactivities Human, Mouse, Porcine, Primate, Xenopus, Zebrafish, Cow, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen A synthetic peptide made to an N-terminal region (within residues 1-50) of the human ATG5 protein. [Swiss-Prot# Q9H1Y0]
Formulation PBS plus 30% glycerol and 0.1% sodium azide
Concentration lot specific
Purification peptide affinity purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name autophagy related 5
Background Autophagy is an important mechanism for nonselective intracellular breakdown whereby cytosol and organelles are encapsulated in vesicles, which are then engulfed and digested by lytic vacuoles/lysosomes. ATG5 is required for autophagy. It conjugates to ATG12 and associates with isolation membrane to form autophagosomes. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. Conjugation to ATG12 is essential for autophagy, but is not required for association with isolation membrane. ATG5 also plays an important role in the apoptotic process. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity.
Synonyms APG5; APG5-LIKE; APG5L; ASP; hAPG5
Reference Data
Protein Families Druggable Genome
Protein Pathways Regulation of autophagy, RIG-I-like receptor signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.