SCARB1 Rabbit Polyclonal Antibody

CAT#: TA301489

Rabbit Polyclonal Antibody against SR-BI

Product Images

Detection of SR-BI in 25 ug of mouse liver lysate, using anti-SRBI at a 1:1,000 dilution, shows distinct band at 82 kDa.

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  Western Blot: SR-BI Antibody [NB400-104] - Detection of SR-BI in rat H4IIE total cell lysates and plasma membrane proteins.

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  Staining of adrenal, cortex

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  Immunohistochemistry: Immunolocalization of SR-BI in adult mink testis using SR-BI Antibody. SR-BI labeling is visible at the surface and along the outline of the large vacuole.

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  Immunocytochemistry/Immunofluorescence: SRB1 antibody was tested at 1:50 in HeLa cells with FITC (green). Nuclei and actin were counterstained with Dapi (blue) and Phalloidin (red).

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Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1: 1000-1:5000
• Reactivities: Hamster, Human, Mink, Mouse, Rat
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A C-terminal peptide containing residues from mouse Scavenger Receptor-BI (within residues 450-509).
• Formulation: Tris-citrate/phosphate [pH 7-8] buffer. and 0.1% Sodium Azide
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: scavenger receptor class B member 1
• Database Link:
  NP_005496
  Entrez Gene 20778 MouseEntrez Gene 25073 RatEntrez Gene 949 Human
  UniProt ID Q8WTV0
• Background: High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis. The SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester. SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidgenic tissues, and mediates selective cholesterol uptake by a distinct mechanism. In mice, it seems that SR-BI plays a key role in determining the levels of plasma lipoprotein cholesterol and the accumulation of cholesterol stores in the adrenal gland.
• Synonyms: CD36L1; CLA-1; CLA1; HDLQTL6; SR-BI; SRB1

Reference Data

• Protein Families: Druggable Genome, Transmembrane