CUG BP1 (CELF1) Mouse Monoclonal Antibody [Clone ID: 3B1]

CAT#: TA301501

Mouse Monoclonal Antibody against CUG-BP1 (3B1)


USD 479.00

5 Days*

Size
    • 100 ul

Frequently bought together (3)
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Specifications

Product Data
Clone Name 3B1
Applications WB
Recommended Dilution Immunohistochemistry: 1:100-1:500, Immunocytochemistry/ Immunofluorescence: 1:50-1:200, Flow Cytometry: 1 ug per million cells, Immunohistochemistry-Frozen: 1:100-1:500, Western Blot: 1:500, Immunohistochemistry-Paraffin: 1:100-1:500, Simple Western: 1:200, Immunoprecipitation, Gel Super Shift Assays
Reactivities Human, Mouse, Rat, Bovine, Porcine, Rabbit
Host Mouse
Isotype IgG1, kappa
Clonality Monoclonal
Immunogen CUG-BP1 human nuclear RNA binding protein.
Formulation Ascitic fluid and 0.1% sodium azide
Concentration lot specific
Purification Ascites
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name CUGBP, Elav-like family member 1
Background Myotonic dystrophy (MD) is an autosomal dominant neuromuscular disease that is associated with a (CTG)n repeat expansion in the 3-untranslated region of the myotonin protein kinase (Mt-PK) gene. A (CUG) n oligonucleotides triplet repeat pre-mRNA/mRNA binding protein may play an important role in DM pathogenesis. HeLa cell protein, CUG-BP1, has been purified based upon its ability to bind specifically to (CUG) 8 oligonucleotides in vitro. CUG-BP1 is the major (CUG) 8 - binding activity in normal cells. CUG-BP1 has been identified as isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. The CUG-BP/hNab50 protein is localized predominantly in the nucleus and is associated with polyadenylated RNAs in vivo. In vitro RNA-binding/photocrosslinking studies demonstrate that CUG-BP/hNab50 binds to RNAs containing the Mt-PK 3' UTR. The (CUG) n repeat region in Mt-PK mRNA is a binding site for CUG-BP/hNab50 in vivo, and triplet repeat expansion leads to sequestration of this hnRNP on mutant Mt-PK transcripts.
Synonyms BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP; hNab50; NAB50; NAPOR
Reference Data
Protein Families Druggable Genome

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.