xCT (SLC7A11) Rabbit Polyclonal Antibody

CAT#: TA301518

Rabbit Polyclonal Antibody against XCT


USD 479.00

2 Weeks*

Size
    • 100 ul

Frequently bought together (1)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

USD 159.00

Specifications

Product Data
Applications IHC, WB
Recommended Dilution Simple Western: 10 ug/ml, Western Blot: 1:1000, Immunocytochemistry/ Immunofluorescence: 1:100-1:1000, Immunohistochemistry-Paraffin: 5 ug/ml, Immunohistochemistry: 5 u/gml, Immunoprecipitation (Negative), Flow Cytometry: 2-3ug/ml, Dual RNAscope ISH-IHC
Reactivities Human, Mouse
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen A synthetic peptide made to a region within the N-terminus of the human XCT protein sequence (between residues 1-50).
Formulation Tris-glycine with 150mM NaCl and 0.05% sodium azide
Purification Immunogen affinity purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name solute carrier family 7 member 11
Background Mammalian amino acid transport systems consist of a large variety of transporters. The amino acid transporter, cystine/glutamic acid transporter xCT, for system xc has been proposed to be responsible for the cystine transport through the plasma membrane. System xc mediates an amino acid exchange and prefers cystine and glutamate as its substrates. The transporter designated as xCT requires 4F2 heavy chain (4F2hc:CD98) for its functional expression, and belongs to the family of amino acid transporters that associates with the type II membrane glycoproteins such as 4F2hc. In brain, it has been proposed that system xc is up-regulated in glial cells upon oxidative stress and plays an essential roles to protect neurons against oxidative stress. Recent studies have implicated xCT as a gateway that Kaposi's sarcoma herpesvirus (KSHV) uses to enter cells.
Synonyms CCBR1; xCT
Reference Data
Protein Families Druggable Genome, Transmembrane

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.