Bcl2 Binding component 3 (BBC3) Rabbit Polyclonal Antibody

CAT#: TA301519

Rabbit Polyclonal Antibody against PUMA


USD 424.00

5 Days*

Size
    • 100 ul

Product Images

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Specifications

Product Data
Applications WB
Recommended Dilution Immunocytochemistry/ Immunofluorescence: 1:20-1:100, Western Blot: 2-4 ug/ml
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen A synthetic peptide made to a region within the C-terminus of the human PUMA protein sequence (between residues 150-193).
Formulation Tris-glycine, 150 mM NaCl, 0.05% sodium azide
Concentration lot specific
Purification Immunogen affinity purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name BCL2 binding component 3
Background A novel gene PUMA (p53 upregulated modulator of apoptosis) is a target for activation by the p53 tumor-suppressor gene. p53 functions as a transcriptional activator, and influences p53-inducible genes that play a role in the induction of apoptosis in response to p53. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.
Synonyms JFY-1; JFY1; PUMA
Reference Data
Protein Families Druggable Genome
Protein Pathways Huntington's disease, p53 signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.