HNRPM (HNRNPM) Mouse Monoclonal Antibody [Clone ID: 2A6]

CAT#: TA301557

Mouse Monoclonal Antibody against Heterogenous Nuclear ribonucleoproteins M3/4 (2A6)

Product Images

Simple Western: hnRNP M Antibody (2A6) TA301557 - Simple Western lane view shows a specific band for hnRNP M in 0.05 mg/ml of HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system.

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  Western Blot: hnRNP M Antibody (2A6) TA301557 - Analysis of hnRNP M3-M4 in HeLa cell lysate.

Specifications

Product Data

• Clone Name: 2A6
• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry: 1:10-1:500, Immunocytochemistry/ Immunofluorescence: 1:10-1:500, Immunoprecipitation: 1:10-1:500, Western Blot: 1:1000, Immunohistochemistry-Paraffin: 1:10-1:500, Immunohistochemistry-Frozen: 1:10-1:500, Simple Western: 1:3000
• Reactivities: Human, Mouse, Rat, Bovine, Porcine, Rabbit
• Host: Mouse
• Isotype: IgG2b, kappa
• Clonality: Monoclonal
• Immunogen: M19 fusion protein containing full-length human protein.
• Formulation: Ascitic fluid and sodium azide
• Purification: Ascites
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: heterogeneous nuclear ribonucleoprotein M
• Database Link:
  NP_112480
  Entrez Gene 76936 MouseEntrez Gene 116655 RatEntrez Gene 4670 Human
  UniProt ID P52272
• Background: Proteins that directly bind to nascent RNA polymerase II transcripts, the heterogenous nuclear ribonucleoproteins (hnRNPs), play an important role in both transcript-specific packaging and alternative splicing of pre-mRNAs. A group of abundant hnRNPs, the M1-M4 proteins, appear as a cluster of four proteins. The M proteins are pre-mRNA binding proteins in vivo, and they bind avidly to poly (G) and poly (U) RNA homopolymers in vitro. M proteins are members of the ribonucleoprotein consensus sequence family of RNA-binding proteins with greatest similarity to a hypothetical RNA-binding protein from Saccharomyces cerevisiae. The M proteins also possess an unusual hexapeptide-repeat region rich in methionine and arginine residues (MR repeat motif) that resembles a repeat in the 64kDa subunit of cleavage stimulation factor, which is involved in 3'-end maturation of pre-mRNAs. Proteins immunologically related to M exist in divergent eukaryotes ranging from human to yeast.
• Synonyms: CEAR; hnRNP M; HNRNPM4; HNRPM; HNRPM4; HTGR1; NAGR1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Spliceosome