CREB1 Rabbit Polyclonal Antibody

CAT#: TA301564

Rabbit Polyclonal Antibody against CREB [Ser121] (Phospho-specific)

Product Images

Detection of phospho-CREB in human HEK 293T cells. Top panel: probed with phosph-CREB. Bottom panel: probed with CREB antibody. Lanes 2 and 4 treated with lambda phosphatase, lanes 3 and 4 treated with 0.2mM H202.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500, IP:5 ug/ml
• Reactivities: Human, Mouse
• Modifications: Phospho-specific
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A phospho-peptide spanning the Ser-121 phosphorylation site of human CREB.
• Formulation: Tris 50% glycerol and 0.05% sodium azide
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: cAMP responsive element binding protein 1
• Database Link:
  NP_004370
  Entrez Gene 12912 MouseEntrez Gene 1385 Human
  UniProt ID P16220
• Background: Cyclic AMP Response Element Binding protein (CREB) is a basic / leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. CREB is also regulated by DNA-damaging stimuli and is directly phosphorylated on Ser-121 by the ataxia-telangiectasia-mutated protein kinase, ATM in response to ionizing radiation.
• Synonyms: CREB

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Antigen processing and presentation, Huntington's disease, Melanogenesis, Prostate cancer