Lipin 1 (LPIN1) Rabbit Polyclonal Antibody

CAT#: TA301605

Rabbit Polyclonal Antibody against LPIN1

Product Images

Immunohistochemistry: LPIN1 Antibody TA301605 - Staining of LPIN1 in mouse pancreas.

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  Western Blot: LPIN1 Antibody TA301605 - Detection of LPIN1 in 3T3L1 lysate.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: Western Blot: 1.0-2.0 ug/ml, Immunohistochemistry: 1:100-1:250, Immunohistochemistry-Paraffin: 1:100-1:250
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide to an internal region (within residues 300-400) of the human LPIN1 protein. [Swiss-Prot# Q14693]
• Formulation: PBS + 30% glycerol and 0.1% sodium azide
• Concentration: lot specific
• Purification: peptide affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: lipin 1
• Database Link:
  NP_663731
  Entrez Gene 14245 MouseEntrez Gene 313977 RatEntrez Gene 23175 Human
  UniProt ID Q14693
• Background: The Lipin family of nuclear proteins contains three members: Lipin-1, Lipin-2 and Lipin-3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin-1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC-1á target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARá. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
• Synonyms: PAP1