TRF2 (TERF2) Rabbit Polyclonal Antibody

CAT#: TA301691

Rabbit Polyclonal Antibody against TRF2


USD 512.00

5 Days*

Size
    • 100 ul

Frequently bought together (1)
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Specifications

Product Data
Applications IHC, WB
Recommended Dilution Knockdown Validated, Flow Cytometry: 1-5 ug/ml, Dot Blot, Western Blot: 1:2000 - 1:5000, Immunocytochemistry/ Immunofluorescence: 1:50 - 1:200, Chromatin Immunoprecipitation (ChIP): 1:10-1:500, ELISA, Immunoprecipitation: 1:10 - 1:500, Simple Western: 1:25, Immunohistochemistry: 1:200, Immunohistochemistry-Paraffin: 1:200
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Baculovirus purified TRF2 protein.
Formulation Tris-glycine, 150mM NaCl, 0.1% BSA. and 0.05% sodium azide
Concentration lot specific
Purification Affinity purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name telomeric repeat binding factor 2
Background TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implied a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types. TRF2 is overexpressed in a number of human tumors and overexpression of TRF2 may be oncogenic.
Synonyms TRBF2; TRF2
Reference Data
Protein Families Transcription Factors

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.