Nucleophosmin (NPM1) Rabbit Polyclonal Antibody

CAT#: TA301725

Rabbit Polyclonal Antibody against Nucleophosmin, mutant - AML Marker

Product Images

Immunocytochemistry/Immunofluorescence: Nucleophosmin Antibody TA301725 - Nucleophosmin localization by immunofluorescence in OCI-AML3 cells.

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  Immunocytochemistry/Immunofluorescence: Nucleophosmin Antibody TA301725 - Nucleophosmin localization by immunofluorescence in HL-60 cells (negative control).

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  Western Blot: Nucleophosmin Antibody TA301725 - Detection of mutant Nucleophosmin in OCI-AML3 lysates.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Immunocytochemistry/ Immunofluorescence: 1:50 - 1:100, Immunohistochemistry: 1:50 - 1:100, Immunohistochemistry-Paraffin: 1:50 - 1:100, Flow Cytometry: 1:100, Immunoprecipitation: 1:50, Western Blot: 1:500
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide made to a C-terminal region of human mutant nucleophosmin (exact sequence is within residues 250-298).
• Formulation: 100 mM glycine, 65 mM Tris, pH 7.0 in 50% glycerol
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: nucleophosmin (nucleolar phosphoprotein B23, numatrin)
• Database Link:
  NP_002511
  Entrez Gene 4869 Human
  UniProt ID P06748
• Background: Nucleophosmin (NPM) is a multi-functional protein that is involved in many cellular activities including cell growth, proliferation and transformation. It is frequently overexpressed in solid tumors, and has recently been found to be mutated and aberrantly localized in the cytoplasm of leukaemic blasts in patients with acute myeloid leukemia (AML).
• Synonyms: B23; NPM

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency, Transcription Factors