APE1 (APEX1) Mouse Monoclonal Antibody [Clone ID: 13B8E5C2]

CAT#: TA301765

Mouse Monoclonal Antibody against APEX1 (13B8E5C2)


USD 479.00

5 Days*

Size
    • 100 ug

Frequently bought together (2)
Transient overexpression lysate of APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 1
    • 100 ug

USD 396.00


beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

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Specifications

Product Data
Clone Name 13B8E5C2
Applications IHC, WB
Recommended Dilution Proximity Ligation Assay, Immunoblotting, ELISA, Chromatin Immunoprecipitation (ChIP): 1:10-1:500, Immunoprecipitation: 1:10 - 1:500, Immunohistochemistry-Frozen: 1:10-1:500, Immunohistochemistry: 1:100, Immunohistochemistry-Paraffin: 1:100, Western Blot: 1:100-1:2000, Simple Western: 1:25, Immunocytochemistry/ Immunofluorescence: 1:50-1:200, Gel Super Shift Assays, Knockdown Validated
Reactivities Human, Mouse, Rat
Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen A fusion protein construct that contains the N-terminal region of human ACAT1.
Formulation PBS and 0.05% sodium azide
Purification Purified human APE/ref protein.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name apurinic/apyrimidinic endodeoxyribonuclease 1
Background The mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is responsible for the repair of AP sites in DNA. In addition, this enzyme functions as a redox factor facilitating the DNA binding capability of FOS, JUN, NfkB, HIF-1 alpha, Pax-5, Pax-8 and other transcription factors. APE/ref-1 has also been shown to control p53 activity through redox alteration. APE is linked to apoptosis, associated with thioredoxin, and altered levels of APE/ref-1 have been found in some cancers. APE appears to form a unique link between the DNA base excision pathway, oxidative signaling, transcription regulation, cancer and cell-cycle control.
Synonyms APE; APE1; APEN; APEX; APX; HAP1; REF1
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency, Transcription Factors
Protein Pathways Base excision repair

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.