P70 S6 Kinase beta (RPS6KB2) Rabbit Polyclonal Antibody

CAT#: TA302019

Rabbit Polyclonal Antibody against RPS6KB2 (Center)

Product Images

Western blot analysis of RPS6KB2 (arrow) using rabbit polyclonal RPS6KB2 Antibody (Center) ([RB11689]). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the human RPS6KB2 gene (Lane 2) (Origene Technologies).

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:1000
• Reactivities: Human, Rat
• Host: Rabbit
• Isotype: Ig
• Clonality: Polyclonal
• Immunogen: This RPS6KB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-272 amino acids from the Central region of human RPS6KB2.
• Formulation: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
• Concentration: lot specific
• Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 53483 Da
• Gene Name: ribosomal protein S6 kinase B2
• Database Link:
  NP_003943
  Entrez Gene 361696 RatEntrez Gene 6199 Human
  UniProt ID Q9UBS0
• Background: RPS6KB2 is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B. Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.
• Synonyms: KLS; p70(S6K)-beta; P70-beta; P70-beta-1; P70-beta-2; p70S6Kb; S6K-beta2; S6K2; SRK; STK14B

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Acute myeloid leukemia, ErbB signaling pathway, Fc gamma R-mediated phagocytosis, Insulin signaling pathway, mTOR signaling pathway, TGF-beta signaling pathway