PDHX Rabbit Polyclonal Antibody
Other products for "PDHX"
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommended Dilution | IF: 1:100, WB: 1:1000, IHC: 1:10~50 |
Reactivities | Human |
Host | Rabbit |
Isotype | Ig |
Clonality | Polyclonal |
Immunogen | This PDX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from human PDX1. |
Formulation | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
Concentration | lot specific |
Purification | This antibody is purified through a protein A column, followed by peptide affinity purification. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 54122 Da |
Gene Name | pyruvate dehydrogenase complex component X |
Database Link | |
Background | PDX1, located in the mitochondrial matrix, is required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. Eukaryotic pyruvate dehydrogenase complexes are organized about a core consisting of the oligomeric dihydrolipoamide acetyl-transferase, around which are arranged multiple copies of pyruvate dehydrogenase, dihydrolipoamide dehydrogenase and protein X bound by noncovalent bonds. Defects in PDHX are a cause of lacticacidemia. PDX1 belongs to the 2-oxoacid dehydrogenase family and contains 1 lipoyl-binding domain. |
Synonyms | DLDBP; E3BP; OPDX; PDX1; proX |
Reference Data |
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